| Gene Symbol | COX10 |
| Aliases | COX10PROTEIN |
| Function | The COX10 gene encodes COX10 Protein, a protein involved in various cellular processes relevant to neuronal function and survival. |
| Primary Expression | various brain regions, with notable expression in:
- Cerebral cortex
- Hippocampus
- Basal gang |
| Subcellular Localization | the inner mitochondrial membrane, where it catalyzes a crucial step in the heme A biosynthetic pathway. Defects in COX10 |
| Molecular Weight | 45 kDa |
| Ensembl ID | ENSG00000171540 |
| GeneCards | COX10 |
| Human Protein Atlas | COX10 |
| COX15 | Protoheme IX oxidase; catalyzes upstream heme A biosynthetic steps |
| Cytochrome c oxidase (Complex IV) | Final electron transport chain complex utilizing heme A |
| Leigh syndrome | Progressive mitochondrial encephalopathy often resulting from COX deficiency |
| Farnesyl pyrophosphate | Substrate for COX10 farnesyltransferase activity |
| Mitochondrial respiratory chain | Oxidative phosphorylation system dependent on functional Complex IV |
| Associated Diseases | Als, Cancer |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |