| Gene Symbol | DSCAM |
| Aliases | DSCAMPROTEIN |
| Chromosome | 21q22.2 |
| Function | DSCAM is one of the largest cell adhesion molecules in the vertebrate genome, with a complex domain architecture that enables diverse functional interactions [@medeot2018]. |
| Subcellular Localization | </th><td>Plasma membrane, axon initial segment, dendritic spines</td></tr> |
| Molecular Weight | 350 kDa |
| GeneCards | DSCAM |
| Human Protein Atlas | DSCAM |
| N-terminal Signal Peptide | Directs protein to the secretory pathway |
| Ig-like Domains (10 total) | Two sets of five Ig domains (D1-D10) that mediate homophilic and heterophilic interactions. The D1 and D2 domains are particularly important for ligand recognition and binding specificity [@bach2018] |
| Fibronectin Type III Domains (6 total) | FNIII domains 1-3 contain binding sites for various ligands, while domains 4-6 are involved in receptor dimerization |
| Transmembrane Domain | Single-pass transmembrane helix anchors DSCAM to the plasma membrane |
| Cytoplasmic Tail | Contains multiple conserved motifs including: |
| Exon 4 variability | The Ig2 domain shows the highest diversity with 48 possible alternative exons |
| Exon 17 variability | Ig9 domain alternatively spliced with 33 options |
| Associated Diseases | Alzheimer's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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