| Gene Symbol | GALECTIN3 |
| Full Name | Galectin-3 |
| Aliases | GALECTIN3PROTEIN |
| Chromosome | 14q22.3 |
| Protein Type | Protein |
| Function | is a member of the galectin family of beta-galactoside-binding lectins that plays a multifaceted role in neurodegenerative disease pathogenesis. |
| Primary Expression | microglia, the resident immune cells of the brain, where it serves as a key marker of disease-associated microglia (DAM) or neurodegenerative microgli |
| Subcellular Localization | </b></td><td>Cytoplasm, nucleus, cell surface, extracellular</td></tr> |
| Exons | 6 |
| UniProt ID | Search UniProt |
| GeneCards | GALECTIN3 |
| Human Protein Atlas | GALECTIN3 |
| Galectin-3 inhibitors | Small molecule inhibitors and natural compounds that block galectin-3 carbohydrate binding |
| Monoclonal antibodies | Anti-galectin-3 antibodies to neutralize extracellular galectin-3 |
| Gene therapy | RNA-based approaches to reduce galectin-3 expression |
| Associated Diseases | Alzheimer's disease |
| Known Drugs/Compounds | Berbamine hydrochloride |
| Interactions | CLEC7A, ALZHEIMER, TREM2 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |