| Catalytic Subunit [@ref]
[Presenilin-1](/proteins/presenilin-1) (PSEN1) or [Presenilin-2](/entities/psen2) (PSEN2) [@ref2017]
[@ref2009]
[@refa]
Subunits [@refb]
Presenilin, Nicastrin, APH-1, PEN-2 [@refc]
[@idf]
[@page2026]
UniProt (PSEN1) [@allen]
P49768 [@allena]
[@allenb]
[@allenc]
PDB [@brainspan]
5A63, 6IDF, 5FN2 [@proteins]
[@adam]
[@amyloidbeta]
Complex Weight [@appprotein]
~230 kDa [@betasecretase]
[@presenilin]
[@refd]
TM Domains [@refe]
20 transmembrane helices (total) [@qbi]
[@qnz]
[@reff]
Localization [@refg]
Plasma membrane, endosomes, ER-Golgi
Enzyme Class | Intramembrane aspartyl protease (GxGD type) |