biomarker 2,754 words KG: BIOMARKERS 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Synaptic Biomarkers in Neurodegeneration

🔬 Protein Info
Gene SymbolBIOMARKERS
Presynaptic proteinsSynaptophysin, Synaptotagmin, SNAP-25, SV2
Postsynaptic proteinsPSD-95, SynGAP, NMDA/AMPA receptor subunits
Synaptic vesiclesSynucleins, Rab proteins
Activity-dependent markersNeurogranin, NPTX2
Associated DiseasesNeurocognitive Disorders, Prostate Cancer, ALS, Frailty, Hepatocellular Carcinoma, Inclusion Body Myositis
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (15)

Yoga Therapy for Neurodegeneration
therapeutic · Pages share 139 hypotheses
YAP/TEAD Pathway Modulators for Neurodegeneration
therapeutic · Pages share 139 hypotheses
Wnt Signaling Modulators for Neurodegeneration
therapeutic · Pages share 139 hypotheses
vitamin-d-therapy-neurodegeneration
therapeutic · Pages share 139 hypotheses
Vitamin B Complex Therapy for Neurodegeneration
therapeutic · Pages share 139 hypotheses

Knowledge Graph (1 edges)

C1Q associated_with BIOMARKERS