| Gene Symbol | GEMIN4 |
| Aliases | GEMIN4PROTEIN |
| Chromosome | 17p13.2 |
| Function | is a critical component of the SMN (Survival Motor Neuron) complex, which is essential for the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs). |
| Primary Expression | human tissues with highest expression in the brain, spinal cord, and testis [1](https://pubmed |
| Subcellular Localization | </th><td>Nucleus (Cajal bodies), cytoplasm</td></tr> |
| Molecular Weight | 116 kDa |
| Amino Acids | 058 aa |
| Exons | 15 |
| Ensembl ID | ENSG00000176490 |
| GeneCards | GEMIN4 |
| Human Protein Atlas | GEMIN4 |
| N-terminal domain | Mediates interaction with Gemin3 and other SMN complex components. This region contains conserved motifs for protein-protein interactions and is essential for complex stability. |
| C-terminal region | Harbors putative nuclear localization signals (NLS) and mediates interactions with additional cellular proteins. The C-terminus also contains potential post-translational modification sites. |
| Oligomerization capacity | Gemin-4 can form higher-order oligomers, potentially creating multivalent interaction surfaces for SMN complex assembly |
| Associated Diseases | ALS through multiple mechanisms [4](https://pubmed |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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