| Gene Symbol | GNA12PROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | to the Plasma membrane, Cytoskeleton |
| GeneCards | GNA12PROTEIN |
| Human Protein Atlas | GNA12PROTEIN |
| GTP-binding domain | Binds GTP/GDP and undergoes conformational changes |
| Helical domain | Covers the nucleotide-binding pocket |
| Effector-binding interface | Interacts with downstream target proteins |
| Gq/11 | Activate phospholipase C-beta (PLCβ), leading to IP3/DAG production and calcium release |
| G12/13 | Activate RhoGEFs, regulating cytoskeletal remodeling and cell migration |
| Gi/o | Inhibit adenylate cyclase and activate GIRK channels |
| Associated Diseases | Als, Schizophrenia |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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