| Gene Symbol | GRAMD1B |
| Aliases | Page for GRAMD1B Protein |
| Chromosome | 11q13.4 |
| Function | GRAMD1B (GRAM Domain Containing 1B, also known as VIPAR) is a 559-amino acid protein encoded by the GRAMD1B gene (NCBI Gene: 54550). |
| Subcellular Localization | primarily to the endoplasmic reticulum (ER) and endosomes, where it participates |
| Molecular Weight | 65 kDa |
| Amino Acids | 762 aa |
| Pathways | mTOR |
| GeneCards | GRAMD1B |
| Human Protein Atlas | GRAMD1B |
| Autophagosome biogenesis and maturation | GRAMD1B interacts with the HOPS (Homotypic fusion and vacuole protein sorting) complex and VPS33A to regulate autophagosome-lysosome fusion[@mcgough2018] |
| Endolysosomal trafficking | Controls trafficking between endosomes and lysosomes through interactions with the retromer complex[@cullen2009] |
| Lipid homeostasis | The START domain facilitates transfer of sterols and phospholipids between membrane compartments[@iaea2017] |
| Cellular stress responses | Upregulated during ER stress and participates in the unfolded protein response (UPR)[@kimata2017] |
| Associated Diseases | Ovarian Cancer |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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