| Gene Symbol | G Protein-Coupled Receptor Kinase 6 |
| Aliases | GRK6PROTEIN |
| Chromosome | 5q33.1 |
| Protein Type | Receptor |
| Function | is a member of the G protein-coupled receptor kinase (GRK) family that plays essential roles in regulating GPCR signaling through receptor phosphorylation, desensitization, and internalization [1]. |
| Primary Expression | the brain and testis, with important functions in the central nervous system |
| Subcellular Localization | </strong></td><td>Plasma membrane, cytoplasm</td></tr> |
| UniProt ID | P43250 |
| NCBI Gene ID | 1568 |
| Ensembl ID | ENSG00000161504 |
| GRK6A | Full-length isoform with N-terminal calcitonin receptor-like receptor binding domain |
| GRK6B | Truncated isoform with alternative N-terminus |
| GRK6C | Short isoform lacking the RGS (Regulator of G protein Signaling) domain |
| RGS-like domain | Facilitates interactions with G protein subunits |
| Phosphorylation sites | Multiple serine/threonine residues for regulation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!