| Gene Symbol | GRM1PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ** | Cell membrane, postsynaptic density | |
| Molecular Weight | 150 kDa |
| GeneCards | GRM1PROTEIN |
| Human Protein Atlas | GRM1PROTEIN |
| Venus flytrap domain (VFT) | Binds glutamate and other agonists |
| Cysteine-rich domain (CRD) | Links VFT to transmembrane domain |
| Dimerization interface | Forms functional homodimers or heterodimers with GRM5 |
| Seven transmembrane helices (7TM) | Typical GPCR structure |
| Conserved motifs | For G protein coupling |
| Allosteric binding sites | For positive and negative allosteric modulators |
| C-terminal tail | Contains PDZ-binding motifs and phosphorylation sites |
| G protein coupling domain | Activates Gq/11 proteins |
| Associated Diseases | neurodegeneration |
| Interactions | MTOR |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!