| Gene Symbol | HSP105 |
| Aliases | HSP105PROTEIN |
| Function | Hsp105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | </th><td>Cytoplasm, Nucleus, Cytosol</td></tr> |
| Molecular Weight | 105 kDa |
| GeneCards | HSP105 |
| Human Protein Atlas | HSP105 |
| N-terminal EEVD Motif | Client protein binding domain |
| ATPase Domain (NBD) | Nucleotide-binding domain at N-terminus (~45 kDa) |
| Substrate-Binding Domain (SBD) | Peptide-binding domain at C-terminus (~35 kDa) |
| Lid Domain | Flexible lid covering the SBD |
| Alternative Splicing | Produces Hsp105α (full-length) and Hsp105β (truncated) isoforms |
| Co-chaperone Activity | Regulates Hsc70/Hsp70 ATPase cycle |
| Protein Refolding | Assists in refolding stress-denatured proteins |
| Aggregation Prevention | Prevents protein aggregation |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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