| Gene Symbol | HTR7PROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | brain regions affected by AD and modulates hippocampal signaling |
| Subcellular Localization | ** | Plasma membrane, dendritic shafts | |
| Molecular Weight | 50 kDa |
| GeneCards | HTR7PROTEIN |
| Human Protein Atlas | HTR7PROTEIN |
| Long third intracellular loop | Contains multiple serine/threonine residues for phosphorylation |
| Differential splicing | Produces three splice variants (HTR7a, HTR7b, HTR7d) with different C-termini |
| Constitutively active | Exhibits basal signaling in the absence of agonist |
| Circadian rhythm | Suprachiasmatic nucleus HTR7 modulates circadian photoentrainment |
| Sleep-wake regulation | Cortical HTR7 promotes wakefulness |
| Thermoregulation | Hypothalamic HTR7 controls body temperature |
| Mood and emotion | Limbic system HTR7 affects anxiety and depression-like behavior |
| Learning and memory | Hippocampal HTR7 modulates synaptic plasticity |
| Associated Diseases | depression |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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