| Gene Symbol | ITCH |
| Aliases | ITCHPROTEIN |
| Function | ITCH (Itchy Homolog, E3 Ubiquitin Protein Ligase) is a HECT-type E3 ubiquitin ligase belonging to the NEDD4 family. It plays critical roles in protein quality control, signal transduction, and immu... |
| Subcellular Localization | </span><span class="infobox-value">Cytoplasm, Nucleus, Endoplasmic reticulum</span></div> |
| Pathways | MAPK, PI3K, NF-κB |
| GeneCards | ITCH |
| Human Protein Atlas | ITCH |
| C2 Domain (1-150) | Calcium-dependent phospholipid binding, membrane targeting |
| WW Domain 1 (172-205) | Protein-protein interaction, PY motif binding |
| WW Domain 2 (214-247) | Protein-protein interaction, PY motif binding |
| WW Domain 3 (258-291) | Protein-protein interaction, PY motif binding |
| WW Domain 4 (328-361) | Protein-protein interaction, PY motif binding |
| HECT Domain (450-903) | Ubiquitin ligase catalytic activity |
| Synaptic plasticity | Controls AMPA receptor trafficking and synaptic strength |
| Protein quality control | Targets misfolded proteins for degradation |
| Interactions | LYSOSOME, UBIQUITIN |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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