Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LYSOSOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LYSOSOME is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 1128 entities in the SciDEX knowledge graph.
| Gene Symbol | LYSOSOME |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Calcium Signaling |
| GeneCards | LYSOSOME |
| Human Protein Atlas | LYSOSOME |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer Disease, Amyotrophic Lateral Sclerosis |
| Interactions | MAVS, RB1, EGFR, RPTOR, MTORC1, LRRK2 |
| KG Connections | 2057 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LYSOSOME["LYSOSOME"] -->|"associated"| NEURON["NEURON"]
LYSOSOME["LYSOSOME"] -->|"associated"| TAU["TAU"]
LYSOSOME["LYSOSOME"] -->|"associated"| PRKN["PRKN"]
LYSOSOME["LYSOSOME"] -->|"associated"| VCP["VCP"]
LYSOSOME["LYSOSOME"] -->|"interacts"| ALS["ALS"]
LYSOSOME["LYSOSOME"] -->|"interacts"| Fibrosis["Fibrosis"]
ATG5["ATG5"] -->|"associated"| LYSOSOME["LYSOSOME"]
ATG7["ATG7"] -->|"associated"| LYSOSOME["LYSOSOME"]
APP["APP"] -->|"associated"| LYSOSOME["LYSOSOME"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| LYSOSOME["LYSOSOME"]
style LYSOSOME fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | regulates | gene | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Infection | activates | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| Proteasome | activates | pathway | 1.00 |
| GENES | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Neurodegeneration | regulates | disease | 0.95 |
| Cancer | activates | disease | 0.95 |
| Alzheimer | activates | disease | 0.95 |
| Parkinson | therapeutic_target | disease | 0.95 |
| Autophagy | causes | pathway | 0.90 |
| CANCER | activates | gene | 0.90 |
| ALZHEIMER | activates | gene | 0.90 |
| MTOR | activates | gene | 0.90 |
| ALZHEIMER'S DISEASE | activates | gene | 0.90 |
| PARKINSON | therapeutic_target | gene | 0.90 |
| DNA | therapeutic_target | gene | 0.90 |
| GENES | activates | gene | 0.90 |
| DNA | regulates | gene | 0.90 |
| MITOCHONDRIA | activates | gene | 0.90 |
| Mitophagy | activates | pathway | 0.90 |
| Alzheimer | therapeutic_target | disease | 0.85 |
| Aging | therapeutic_target | disease | 0.85 |
| Neurodegeneration | therapeutic_target | disease | 0.85 |
| Infection | therapeutic_target | disease | 0.85 |
| Als | interacts_with | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | associated_with | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | regulates | pathway | 0.94 |
| AUTOPHAGY | involved_in | entity | 0.92 |
| RUBCN | regulates | entity | 0.90 |
| SDC1 | translocates_to | entity | 0.90 |
| MITOCHONDRIAL-DERIVED VESICLES | translocates_to | entity | 0.90 |
| FCRN | protects_against | entity | 0.90 |
| NEURODEGENERATION | activates | gene | 0.90 |
| PINK1 | regulates | gene | 0.90 |
| ROS | activates | gene | 0.90 |
| MITOPHAGY | activates | gene | 0.90 |
| TREHALOSE | modulates | entity | 0.85 |
| TFEB | regulates | protein | 0.84 |
| MITOPHAGY | regulates | gene | 0.80 |
| APOPTOSIS | regulates | gene | 0.80 |
| ATG | regulates | gene | 0.80 |
| LYSOSOMAL BIOGENESIS | activates | gene | 0.80 |
| MITOPHAGY | associated_with | gene | 0.80 |
| NEURODEGENERATION | regulates | gene | 0.80 |
| NEURODEGENERATION | therapeutic_target | gene | 0.80 |
| AUTOPHAGY | inhibits | gene | 0.80 |
| TFEB | activates | gene | 0.80 |
| C9ORF72 | associated_with | gene | 0.75 |
| APOPTOSIS | associated_with | gene | 0.70 |
| P62 | activates | gene | 0.70 |
| LC3 | activates | gene | 0.70 |
| PIK3C3 | regulates | gene | 0.70 |
| AUTOPHAGY | causes | gene | 0.70 |
| SNAP29 | regulates | gene | 0.70 |
| SQSTM1 | activates | gene | 0.70 |
| PTEN | regulates | gene | 0.70 |
| PINK1 | activates | gene | 0.70 |
| AGING | therapeutic_target | gene | 0.70 |
| NLRP3 | activates | gene | 0.70 |
| TNF | activates | gene | 0.70 |
| IL1B | activates | gene | 0.70 |
| NEUROTOXICITY | activates | gene | 0.70 |
| ATG | inhibits | gene | 0.70 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.70 |
| BECN1 | activates | gene | 0.70 |
| ATG | activates | gene | 0.70 |
| ATG5 | activates | gene | 0.70 |
| ATG5 | associated_with | gene | 0.65 |
| ATG7 | associated_with | gene | 0.65 |
| APP | associated_with | gene | 0.65 |
| HUNTINGTON | associated_with | gene | 0.65 |
| ENDOSOME | associated_with | gene | 0.65 |
| LAMP2 | associated_with | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Transcriptional Autophagy-Lysosome Coupling | 0.665 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso | 0.542 | neurodegeneration | What molecular mechanisms link elevated |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798] | Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang | Cell Mol Gastroenterol Hepatol | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466] | Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji | J Ethnopharmacol | 2022 | 1 |
| Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892] | Wang Y, An H, Liu T, Qin C, Sesaki H, Gu | Cell Rep | 2019 | 1 |
| AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310] | Song X, Zhu S, Chen P, Hou W, Wen Q, Liu | Curr Biol | 2018 | 1 |
| Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664] | Cid-Díaz T, Santos-Zas I, González-Sánch | J Cachexia Sarcopenia Muscle | 2017 | 1 |
| PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736] | Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K | Cell reports | 2026 | 0 |
| Mammalian lipophagy: process and function. [PMID:41681129] | Zhao R, Dai E, Kang R, Liu J, Klionsky D | Autophagy | 2026 | 0 |
| TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828] | ["Xin Y", "Sun Y", "Pan E", "Li M", "Che | Free radical biology & medicin | 2026 | 0 |
| Combining network pharmacology and multi-omics reveals the role of Shengdihuang- [PMID:41655545] | Cao X, Shang Y, Qu M, Kang Q, Xu Y et al | Phytomedicine | 2026 | 0 |
| A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling an [PMID:41718717] | Golec DP, Gazzinelli-Guimaraes PH, Chaus | J Exp Med | 2026 | 0 |
| Comparative transcriptomics of adherent and suspension chicken fibroblast cell l [PMID:41763754] | Contreras EJ, Nagarajan A, Bromberg BH, | Food Res Int | 2026 | 0 |
| FOXO1 transcription factor modulates airway epithelial responses to viral infect [PMID:41931532] | Daniel NM, Mann-Nüttel R, Shrestha Palik | PLoS One | 2026 | 0 |
| Clinical and immunological significance of FOXO1 as a biomarker of improved resp [PMID:41935603] | Du L, Wang J, Wang Y, Wang H, Xu X et al | Eur J Pharmacol | 2026 | 0 |
| Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cell [PMID:41945556] | Yan Z, Chi W, Yan Z, Wang H | PLoS One | 2026 | 0 |
| Ponatinib inhibits LCK and PI3K signaling and promotes CD8(+) T stem cell memory [PMID:41946709] | Okuhiro Y, Ito S, Watanabe K, Yan Y, Kum | Nat Commun | 2026 | 0 |
| Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerb [PMID:41950099] | Oyabu M, Sakaue M, Kubo A, Yoshioka K, K | Proc Natl Acad Sci U S A | 2026 | 0 |
| The deubiquitinase activity of CYLD is required for B cell differentiation. [PMID:41951576] | Pseftogas A, Bordini J, Gavriilidis G, F | Cell Death Dis | 2026 | 0 |
| Effects of Vitamin A Restriction on Carcass Characteristics, Antioxidant Capacit [PMID:41856090] | Zhang X, Zhang C, Song J, Bai J, Hao B, | Animal bioscience | 2026 | 0 |
| Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-medi [PMID:41907189] | Bennett KR, Surles-Zeigler MC, Augello C | Frontiers in molecular neurosc | 2026 | 0 |