| Gene Symbol | KINESIN1A |
| Aliases | KINESIN1APROTEIN |
| Function | Kinesin-1 Heavy Chain (KIF5A) is a motor protein that transports cargo along microtubules from the cell body toward the synaptic terminal (anterograde transport). |
| Subcellular Localization | </strong></td><td>Axons, Dendrites</td></tr> |
| GeneCards | KINESIN1A |
| Human Protein Atlas | KINESIN1A |
| N-terminal motor domain (aa 1-340) | Contains the microtubule-binding site and ATP-binding pocket that powers conformational changes for movement |
| Coiled-coil stalk domain (aa 340-700) | Mediates dimerization with the other heavy chain and cargo adaptor binding |
| C-terminal tail domain (aa 700-963) | Regulates motor activity and cargo binding specificity |
| Synaptic vesicle precursors | Transport of synaptic vesicle proteins from the cell body to presynaptic terminals |
| Mitochondria | Distribution of mitochondria along axons to meet energy demands at synaptic sites |
| Neurotrophin receptors | Trafficking of Trk receptors for neurotrophic signaling |
| RNA granules | Transport of mRNAs and translation machinery for local protein synthesis |
| Protein complexes | APP and BACE transport relevant to amyloidogenesis |
| Light chain binding | KLC proteins link KIF5A to specific cargoes |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |