Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy

graph TD
    A["Miro1/RHOT1 Gene"] --> B["Miro1 GTPase on Outer Mitochondrial Membrane"]
    B --> C["Milton/TRAK Adaptor Binding"]
    C --> D["Kinesin Motor Complex"]
    C --> E["Dynein Motor Complex"]

    D --> F["Anterograde Transport"]
    E --> G["Retrograde Transport"]
    F --> H["Mitochondria to Synaptic Terminals"]
    G --> I["Damaged Mitochondria to Soma"]

    J["Neurodegeneration"] --> K["Miro1 Dysfunction"]
    K --> L["Impaired Mitochondrial Trafficking"]
    L --> M["Synaptic Energy Deficit"]
    L --> N["Failed Mitophagy"]

    M --> O["Synaptic Dysfunction"]
    N --> P["Damaged Mito Accumulation"]
    P --> Q["Oxidative Stress"]

    R["Miro1 Enhancement Therapy"] --> S["Restore Miro1-TRAK Interaction"]
    S --> T["Normalize Anterograde Transport"]
    S --> U["Restore Retrograde Transport"]

    T --> V["Synaptic Mitochondrial Supply"]
    U --> W["Efficient Damaged Mito Clearance"]

    V --> X["Restored Synaptic ATP"]
    W --> Y["Reduced ROS"]
    X --> Z["Neuroprotection"]
    Y --> Z

    style J fill:#4a1942,stroke:#ce93d8,color:#e0e0e0
    style R fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style V fill:#1a3a2a,stroke:#81c784,color:#e0e0e0
    style Z fill:#2a3a1a,stroke:#c5e1a5,color:#e0e0e0