protein 1,505 words KG: LDLRAD3PROTEIN 2026-03-27
kind:proteinsection:proteinsstate:publishedtopic:alzheimerstopic:lipid-metabolism
Contents

LDLRAD3 (LDLR Adapter Protein 1) Protein

🔬 Protein Info
Gene SymbolLDLRAD3
AliasesLDLRAD3PROTEIN
Chromosome1p31.3
Protein FamilyLDLR adapter family
FunctionThe LDLRAD family consists of LDLRAD1, LDLRAD2, LDLRAD3, and LDLRAD4, each with distinct expression patterns and functions.
Subcellular Localization** | Cell membrane, Cytoplasm |
Molecular Weight~47 kDa (407 amino acids)
UniProt IDQ8IY81
GeneCardsLDLRAD3
Human Protein AtlasLDLRAD3
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.48
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Membrane Cholesterol Gradient Modulators
Score: 0.52
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (4)

AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Sex Differences in Alzheimer's Disease — mechanisms and ther
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Extracellular Vesicle and Tunneling Nanotube-Mediated S
mechanism · Pages share 5 hypotheses
ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT
clinical · Pages share 5 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 5 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 5 hypotheses