| Gene Symbol | METTL14 |
| Aliases | m6A Methyltransferase Subunit |
| Function | METTL14 (Methyltransferase Like 14) is a 456-amino acid protein that forms the substrate recognition component of the m6A methyltransferase complex. |
| Subcellular Localization | </strong> Nucleus, cytosol</div>
<div class="infobox-row"><strong>Protein Fami |
| Molecular Weight | 59.6 kDa |
| Amino Acids | 456 aa |
| GeneCards | METTL14 |
| Human Protein Atlas | METTL14 |
| Substrate Recognition | The METTL14 subunit recognizes and binds specific mRNA sequences, determining which transcripts get methylated |
| Synaptic mRNA Regulation | The complex regulates the translation of synaptic proteins through m6A modification of their mRNAs, affecting synaptic plasticity and memory formation |
| Neuronal Differentiation | m6A modification regulates the timing of neuronal differentiation during development by controlling key transcription factor mRNAs |
| Axonal Regeneration | METTL14-mediated m6A modification regulates the regenerative capacity of neurons after injury |
| Glial Function | Important for oligodendrocyte precursor cell differentiation and myelin formation |
| Small Molecule Modulators | Compounds that enhance METTL14-METTL3 interaction could boost m6A modification of neuroprotective transcripts |
| RNA-Based Therapeutics | m6A-modified mRNA therapeutics could bypass defective methylation to express therapeutic proteins |
| Interactions | NESTIN |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |