gene

NESTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NESTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

168Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

Summary

NESTIN is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NESTIN
Chromosome	1q23.1
Protein Family	Class VI intermediate filaments
Function	is a protein encoded by the NES gene.
Primary Expression	neural stem and progenitor cells during development and in adult neurogenic regions[@reynolds1992]:
Subcellular Localization	Cytoplasm, intermediate filaments
Molecular Weight	220 kDa
Amino Acids	4477 aa
Pathways	Circadian Rhythm, Mapk, Mitochondrial Function, Wnt
UniProt ID	P48681
NCBI Gene ID	4756
Ensembl ID	ENSG00000132688
GeneCards	NESTIN
Human Protein Atlas	NESTIN
N-terminal head domain	Highly charged, involved in protein-protein interactions
Associated Diseases	Neurodevelopmental disorders, Brain tumors, Alzheimer's disease, Parkinson's disease, Stroke
Interactions	NOTCH1, GFAP, SOX2, PIK3R3, AKT, PI3K
KG Connections	168 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NESTIN — AlphaFold P48681 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

gene · 1827 words

→

Pathway Diagram

graph TD
    NESTIN["NESTIN"]
    NESTIN -->|"expressed in"| Als["Als"]
    NESTIN -->|"activates"| Ischemia["Ischemia"]
    NESTIN -->|"interacts"| Alzheimer["Alzheimer"]
    NESTIN -->|"interacts"| Ms["Ms"]
    NESTIN -->|"activates"| Cardiovascular["Cardiovascular"]
    NESTIN -->|"activates"| Depression["Depression"]
    SOX2["SOX2"] -->|"expressed in"| NESTIN
    EGF["EGF"] -->|"expressed in"| NESTIN
    GFAP["GFAP"] -->|"expressed in"| NESTIN
    DLK2["DLK2"] -->|"expressed in"| NESTIN
    ALDH1L1["ALDH1L1"] -->|"expressed in"| NESTIN
    GENES["GENES"] -->|"expressed in"| NESTIN
    NGF["NGF"] -->|"activates"| NESTIN
    DCX["DCX"] -->|"activates"| NESTIN
    BDNF["BDNF"] -->|"activates"| NESTIN
    HES1["HES1"] -->|"activates"| NESTIN

Outgoing (124)

Target	Relation	Type	Str
NEURODEGENERATIVE DISEASES	involved_in	disease	0.85
Ischemia	activates	disease	0.75
Als	activates	disease	0.75
Als	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cardiovascular	activates	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Stroke	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
ALS	expressed_in	disease	0.65
ALS	activates	disease	0.65
Obesity	activates	disease	0.65
Autism	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
ALDH1L1	expressed_in	gene	0.60
NOTCH1	expressed_in	gene	0.60
DLK2	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
NOTCH1	activates	gene	0.60
GFAP	activates	gene	0.60
NOTCH1	inhibits	gene	0.60
SOX2	inhibits	gene	0.60
PIK3R3	interacts_with	gene	0.60
AKT	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
ARC	inhibits	gene	0.60
GAIN	activates	gene	0.60
BAX	expressed_in	gene	0.60
DCX	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
BDNF	activates	gene	0.60
TRKB	activates	gene	0.60
MET	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
ARNT	regulates	gene	0.60
GFAP	associated_with	gene	0.60
HES1	inhibits	gene	0.60
OLIG2	associated_with	gene	0.60

Incoming (44)

Source	Relation	Type	Str
SOX2	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
DLK2	expressed_in	gene	0.60
ALDH1L1	expressed_in	gene	0.60
NGF	activates	gene	0.60
DCX	activates	gene	0.60
BDNF	activates	gene	0.60
HES1	activates	gene	0.60
ALDH1L1	inhibits	gene	0.60
DLK2	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
BRAF	expressed_in	gene	0.60
SOX2	associated_with	gene	0.60
VIMENTIN	expressed_in	gene	0.60
AKT	inhibits	gene	0.60
ARC	inhibits	gene	0.60
GFAP	associated_with	gene	0.60
MET	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
PI3K	activates	gene	0.60
PROGRANULIN	expressed_in	gene	0.60
NOTCH1	expressed_in	gene	0.60
SP1	activates	gene	0.60
DKK1	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
ERK	inhibits	gene	0.60
BCL-2	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
SYNAPSE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
RAS	activates	gene	0.60
STROKE	activates	gene	0.60
AND	associated_with	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
WNT	regulates	gene	0.60
MAPK	regulates	gene	0.60
AND	activates	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
NOTCH	expressed_in	gene	0.60
STAT3	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NESTIN

Understanding Entity Pages

Summary

Wiki Pages (21)

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

nf1-protein

Niemann-Pick Disease Type C (NPC)

Neurogenesis

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Neurogenesis and Neurodegeneration

SETD1B

Adult Neurogenesis in Neurodegenerative Disease

Neuronal Migration

Tanycytes: A Novel Tau Clearance Pathway from Brain to Blood

Tanycytes

Adult Neurogenesis in Neurodegeneration

TERT Gene

Hippocampal Neurogenesis in Neurodegeneration

DVL3 — Dishevelled Segment Polarity Protein 3

CFLAR

alexander-disease

FZD8 Protein

SMAD5 — SMAD Family Member 5