protein 627 words KG: PER2PROTEIN 2026-03-17
kind:proteinsection:proteinsstate:published
Contents

PER2 Protein

🔬 Protein Info
Gene SymbolPeriod Circadian Regulator 2
Chromosome2p13
FunctionPER2 is a core clock gene essential for circadian rhythm generation.
Subcellular Localization</strong></td><td>Nucleus (primary), Cytoplasm</td></tr>
Molecular Weight180 kDa
PathwaysAkt, Circadian Rhythm, Lipid Metabolism, Mtor, Pi3K
UniProt IDQ8BZD0
NCBI Gene ID8864
Ensembl IDENSG00000132266
OMIM603714
Associated Diseasesneurodegeneration
KG Connections2 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Circadian-Metabolic Microglial Reprogramming
Score: 0.46
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: associated_with

Knowledge Graph (2 edges)

PER2PROTEIN participates_in circadian rhythm
PER2PROTEIN associated_with neurodegeneration