protein 656 words KG: PMCA1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

PMCA1 Protein — Plasma Membrane Calcium ATPase 1

🔬 Protein Info
Gene SymbolPMCA1PROTEIN
AliasesPMCA1PROTEIN
Chromosome12q21.33
Subcellular Localizations, allowing tissue-specific regulation of calcium extrusion. The protein localizes to the plasma membrane throughout the
ATP2B2, ATP2B3, ATP2B4Other PMCA isoforms with distinct tissue distributions
CalmodulinRegulatory protein essential for PMCA1 activation
NCX1Sodium-calcium exchanger providing alternative calcium extrusion mechanism
CalpainDownstream effector of calcium toxicity
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Membrane Cholesterol Gradient Modulators
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Lysosomal Membrane Repair Enhancement
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in