| Gene Symbol | PON2 |
| Full Name | Paraoxonase 2 |
| Aliases | PON2PROTEIN |
| Chromosome | 7q21.3 |
| Function | 1. ROS reduction: PON2 inhibits mitochondrial ROS production by modulating Complex I activity |
| Primary Expression | the liver and secreted into the plasma, PON2 exhibits a broader tissue distribution with particularly high expression in the brain, lung, and heart |
| Subcellular Localization | ** | Endoplasmic Reticulum, Mitochondria, Cytoplasm | |
| Amino Acids | 354 aa |
| UniProt ID | [Q15165](https://www.uniprot.org/uniprot/Q15165) |
| Ensembl ID | ENSG00000105855 |
| GeneCards | PON2 |
| Human Protein Atlas | PON2 |
| Six-bladed beta-propeller | Catalytic core of the enzyme |
| Unique N-terminus | Lacks the N-terminal signal peptide present in PON1/PON3, explaining intracellular localization |
| Active site | Contains residues critical for lactonase and hydrolytic activity |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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