protein 3,677 words KG: PRION_PROTEIN
Contents

Prion Protein (PRNP)

🔬 Protein Info
Gene SymbolPRNP
AliasesPRION_PROTEIN
Chromosome20p13
Protein FamilyPrion protein family
Functionis a GPI-anchored glycoprotein expressed predominantly in the central nervous system.
Primary ExpressionCell membrane ( GPI-anchored), cytoplasm, nucleus
Subcellular LocalizationCell membrane ( GPI-anchored), cytoplasm, nucleus
Molecular Weight33-35 kDa (253 amino acids)
Amino Acids253 aa
UniProt IDP04156
GeneCardsPRNP
Human Protein AtlasPRNP
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (58)

Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
RNA Granule Nucleation Site Modulation
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
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Related Analyses (16)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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