protein 3,677 words KG: PRION_PROTEIN
Contents

Prion Protein (PRNP)

🔬 Protein Info
Gene SymbolPRNP
AliasesPRION_PROTEIN
Chromosome20p13
Protein FamilyPrion protein family
Functionis a GPI-anchored glycoprotein expressed predominantly in the central nervous system.
Primary ExpressionCell membrane ( GPI-anchored), cytoplasm, nucleus
Subcellular LocalizationCell membrane ( GPI-anchored), cytoplasm, nucleus
Molecular Weight33-35 kDa (253 amino acids)
Amino Acids253 aa
UniProt IDP04156
GeneCardsPRNP
Human Protein AtlasPRNP
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (58)

Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Glycosaminoglycan Template Disruption Approach
Score: 0.60
Netrin-1 Gradient Restoration
Score: 0.59
VCP-Mediated Autophagy Enhancement
Score: 0.59
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
← Prevpg 3/3

Related Analyses (16)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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