protein 1,088 words KG: RIC3PROTEIN 2026-03-28
kind:proteinsection:proteinsstate:publishedrole:chaperone
Contents

RIC3 Protein — Acetylcholine Receptor Chaperone

🔬 Protein Info
Gene SymbolRIC3
AliasesRIC3, CHRNA7, AchR-associated protein
Chromosome7p14.3
Protein FamilyRIC3 family
Protein TypeGene
FunctionRIC3 (Resistant to Inhibitors of Cholinesterase 3) is a transmembrane chaperone protein that plays a critical role in the assembly and trafficking of nicotinic acetylcholine receptors (nAChRs).
Primary Expressionneurons and supports synaptic cholinergic signaling
Subcellular LocalizationEndoplasmic reticulum (ER)
Molecular Weight~30 kDa (271 amino acids)
Amino Acids461 aa
UniProt IDQ86XR7
GeneCardsRIC3
Human Protein AtlasRIC3
Protein NameRIC3 (Chaperone Protein)
GeneRIC3
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.51
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (8)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.46
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.46
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.46
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.46
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.46

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in