| Gene Symbol | RPL9PROTEIN |
| Chromosome | 4p13 |
| Function | is a component of the 60S large ribosomal subunit in eukaryotic cells. |
| Subcellular Localization | </th><td>Cytoplasm, ribosome</td></tr> |
| GeneCards | RPL9PROTEIN |
| Human Protein Atlas | RPL9PROTEIN |
| RNA-binding domain | RPL9 contains domains that facilitate binding to the 28S rRNA of the 60S subunit |
| Alpha-helical structure | The protein has a characteristic alpha-helical structure typical of many ribosomal proteins |
| Peptidyl transferase center proximity | RPL9 is positioned near the peptidyl transferase center, where peptide bond formation occurs |
| tRNA interaction sites | The protein contributes to stabilizing tRNA binding at the P-site of the ribosome |
| tRNA stabilization | RPL9 helps stabilize the binding of peptidyl-tRNA at the P-site, which is critical for the accuracy and efficiency of translation |
| Ribosome assembly | RPL9 participates in the assembly of the 60S subunit, integrating with rRNA and other ribosomal proteins to form a functional ribosomal particle |
| Axonal translation | mRNAs are transported to distal neuronal compartments, including growth cones and synaptic terminals, requiring coordinated ribosomal activity for local protein synthesis |
| Protein homeostasis disruption | The accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles is associated with impaired protein quality control systems, including the ribosome |
| Synaptic ribosomal dysfunction | Synaptic compartments are particularly vulnerable to ribosomal dysfunction, contributing to synaptic loss and cognitive decline in AD |
| Associated Diseases | neurodegeneration |
| Interactions | EIF4G2 |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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