gene

EIF4G2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4G2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

8Outgoing

0Incoming

Summary

EIF4G2 (Eukaryotic Translation Initiation Factor 4G2/DAP5) - cap-independent translation regulator involved in cellular stress response, protein homeostasis, neural development, and implicated in Alzheimer's disease, Parkinson's disease, and neurodegenerative processes through translation control mechanisms

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🧬 Gene Info

Gene Symbol	EIF4G2
Aliases	DAP5, NAT1, p97
Chromosome	11p15.4
Function	is a member of the eIF4G family of translation initiation factors that plays critical roles in cap-independent translation, cellular stress responses, and neural development.
Primary Expression	various tissues with particularly high levels in the brain
Molecular Weight	~175 kDa
Amino Acids	560 aa
UniProt ID	Q9U5Y1
NCBI Gene ID	1982
Ensembl ID	ENSG00000109689
OMIM	604353
GeneCards	EIF4G2
Human Protein Atlas	EIF4G2
Gene Name	Eukaryotic Translation Initiation Factor 4G2
Protein Size	1,560 amino acids
Associated Diseases	neurodegeneration
Interactions	RPL9, RPL27A, RPL32, GR, HMG20A
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EIF4G2 — AlphaFold Q9U5Y1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EIF4G2["<b>EIF4G2</b>"]
    GR["GR"]
    EIF4G2 -->|"interacts with"| GR
    HMG20A["HMG20A"]
    EIF4G2 -->|"interacts with"| HMG20A
    PHD2["PHD2"]
    EIF4G2 -->|"regulates"| PHD2
    HIF_1_["HIF-1alpha"]
    EIF4G2 -->|"regulates"| HIF_1_
    eIF2_["eIF2beta"]
    EIF4G2 -->|"binds"| eIF2_
    RPL9["RPL9"]
    EIF4G2 -->|"interacts with"| RPL9
    RPL27A["RPL27A"]
    EIF4G2 -->|"interacts with"| RPL27A
    RPL32["RPL32"]
    EIF4G2 -->|"interacts with"| RPL32
    neurodegeneration["neurodegeneration"]
    EIF4G2 -->|"implicated in"| neurodegeneration
    style EIF4G2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
GR	interacts_with	protein	0.80
HMG20A	interacts_with	protein	0.80
PHD2	regulates	gene	0.80
eIF2β	binds	protein	0.80
HIF-1α	regulates	protein	0.80
RPL9	interacts_with	gene	0.70
RPL27A	interacts_with	gene	0.70
RPL32	interacts_with	gene	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found