protein 1,997 words KG: SCARA1PROTEIN
Contents

SCARA1 Protein

🔬 Protein Info
Gene SymbolSCARA1
Full NameSCARA1 (Scavenger Receptor Class A Member 1)
AliasesScavenger Receptor Class A Member 1
Chromosome8p23.1.
Protein TypeGene
FunctionSCARA1 functions as a scavenger receptor with multiple ligands and functions
Primary ExpressionPrimarily macrophages, also microglia in brain
Molecular Weight49 kDa
Amino Acids471 aa
PathwaysNF-κB
UniProt IDQ9Y6Q9
NCBI Gene ID4451
Ensembl IDENSG00000138206
GeneCardsSCARA1
Human Protein AtlasSCARA1
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (20)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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