protein 1,472 words KG: SENP2PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

SENP2 Protein - SUMO Specific Peptidase 2

🔬 Protein Info
Gene SymbolSENP2
Full NameSUMO Specific Peptidase 2
AliasesPage for SENP2 Protein
Protein FamilySUMO protease family (ULP superfamily)
Protein TypeProtease
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationNucleus, Nuclear envelope
Molecular Weight66.5 kDa
Amino Acids589 aa
PathwaysWnt
UniProt ID[Q9Y2W1](https://www.uniprot.org/uniprot/Q9Y2W1)
GeneCardsSENP2
Human Protein AtlasSENP2
Protein Name [@zhang2008] SUMO-specific protease 2 [@gstmsumo2012] [@bace2015] [@pinkparkinsumo2016] Gene [@huntingtin2013] SENP2 UniProtQ9HC38
Length589 amino acids
Associated Diseasesneurodegeneration
InteractionsATF3
KG Connections7 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

PARP1 Inhibition Therapy
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in