transcription_factor

ATF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

356Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATF3 is an entity related to neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 242 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔮 Predicted Structure: ATF3 — AlphaFold Q9Y2T3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATF3 Gene

gene · 897 words

→

ATF3 Protein

protein · 3024 words

→

Pathway Diagram

graph TD
    ATF3["ATF3"] -->|"regulates"| TREM2["TREM2"]
    ATF3["ATF3"] -->|"exacerbates"| neurodegeneration["neurodegeneration"]
    ATF3["ATF3"] -->|"activates"| Aging["Aging"]
    ATF3["ATF3"] -->|"activates"| Cardiovascular["Cardiovascular"]
    ATF3["ATF3"] -->|"activates"| Fibrosis["Fibrosis"]
    ATF3["ATF3"] -->|"therapeutic target"| Fibrosis_1["Fibrosis"]
    MYO7A["MYO7A"] -->|"activates"| ATF3["ATF3"]
    MAP1LC3B["MAP1LC3B"] -->|"activates"| ATF3["ATF3"]
    OPTN["OPTN"] -->|"activates"| ATF3["ATF3"]
    PARKIN["PARKIN"] -->|"activates"| ATF3["ATF3"]
    style ATF3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (215)

Target	Relation	Type	Str
lipid peroxidation products	increases_risk	mechanism	0.85
Als	activates	disease	0.85
mitochondrial dysfunction	associated_with	mechanism	0.80
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Fibrosis	activates	disease	0.75
Ferroptosis	activates	pathway	0.70
neurons	expressed_in	cell_type	0.70
NF-kB signaling	participates_in	pathway	0.70
Senescence	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Tumor	regulates	disease	0.65
Cardiovascular	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	regulates	disease	0.65
ALS	associated_with	disease	0.65
Stroke	activates	disease	0.65
Aging	causes	disease	0.65
Senescence	associated_with	disease	0.65
Aging	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Hepatitis	activates	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
Infection	therapeutic_target	disease	0.65
Glaucoma	regulates	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Ischemia	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Ms	activates	disease	0.65

Incoming (141)

Source	Relation	Type	Str
SIRT1	activates	unknown	0.95
NAD+ depletion	activates	mechanism	0.95
CANCER	therapeutic_target	gene	0.70
GENES	activates	gene	0.70
FERROPTOSIS	activates	gene	0.70
OPTN	activates	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
XBP1	activates	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
ELAVL1	activates	gene	0.60
ANXA2	activates	gene	0.60
ICAM1	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
CD14	activates	gene	0.60
RGS1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
CEBPA	protects_against	gene	0.60
PTGS2	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
LC3B	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATF3 in their description or question text

No additional research found