| Gene Symbol | SHANK1 |
| Aliases | Postsynaptic Scaffold |
| Chromosome | 19p13 |
| Protein Type | Protein |
| Function | Scaffold Assembly: Shank1 connects membrane proteins to the actin cytoskeleton |
| Molecular Weight | 230 kDa |
| Amino Acids | 2160 aa |
| UniProt ID | Q9Y2X2 |
| GeneCards | SHANK1 |
| Human Protein Atlas | SHANK1 |
| SHANK3 | The most extensively studied family member, primarily linked to autism spectrum disorder and schizophrenia |
| PSD-95 | Primary MAGUK interacting partner essential for SHANK1 recruitment |
| Homer proteins | Coordinate mGluR signaling within SHANK1 complexes |
| Dendritic spines | Primary structural sites where SHANK1 scaffolding occurs |
| Postsynaptic density | The anatomical compartment where SHANK1 functions |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |