gene 830 words KG: SHANK3
Contents

SHANK3 - SH3 and Multiple Ankyrin Repeat Domains 3

🧬 Gene Info
Gene SymbolSHANK3
Full NameSH3 and Multiple Ankyrin Repeat Domains 3
AliasesPage for SHANK3, Page for SHANK3 Protein
Chromosome22q13.33.
FunctionPostsynaptic density assembly: Recruits and organizes synaptic proteins
Molecular Weight180 kDa
Amino Acids620 aa
UniProt ID[Q9BYB0](https://www.uniprot.org/uniprot/Q9BYB0)
Ensembl IDENSG00000132924
GeneCardsSHANK3
Human Protein AtlasSHANK3
Associated DiseasesAls
InteractionsACC, ANK3, CACNA1G, GENES, KCNH7, KMT2A
KG Connections47 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in
SHANK2 Gene
gene · KG edge: regulates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: inhibits
CACNA1G Gene
gene · KG edge: inhibits
KMT2D — Lysine Methyltransferase 2D
gene · KG edge: inhibits

Knowledge Graph (12 edges)

MTOR inhibits SHANK3
SHANK3 inhibits SST
SETD1A inhibits SHANK3
GAIN expressed_in SHANK3
KMT2B inhibits SHANK3
SHANK3 inhibits KMT2D
SHANK3 inhibits CACNA1G
SHANK3 inhibits KMT2A
SHANK3 inhibits KCNH7
KMT2A inhibits SHANK3

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