gene 830 words KG: SHANK3 2026-03-22
kind:genesection:genesstate:published
Contents

SHANK3 - SH3 and Multiple Ankyrin Repeat Domains 3

🧬 Gene Info
Gene SymbolSHANK3
Full NameSH3 and Multiple Ankyrin Repeat Domains 3
AliasesPage for SHANK3, Page for SHANK3 Protein
Chromosome22q13.33.
FunctionPostsynaptic density assembly: Recruits and organizes synaptic proteins
Molecular Weight180 kDa
Amino Acids620 aa
UniProt ID[Q9BYB0](https://www.uniprot.org/uniprot/Q9BYB0)
Ensembl IDENSG00000132924
GeneCardsSHANK3
Human Protein AtlasSHANK3
Associated DiseasesAls
InteractionsSST, KMT2D, CACNA1G, KMT2A, SETD1A, KMT2B
KG Connections49 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
SHANK2 Gene
gene · KG edge: regulates
setd1a
gene · KG edge: inhibits
KMT2D — Lysine Methyltransferase 2D
gene · KG edge: inhibits
KMT2B — lysine methyltransferase 2B
gene · KG edge: inhibits

Knowledge Graph (12 edges)

SHANK3 inhibits SST
SHANK3 inhibits KMT2D
SHANK3 inhibits CACNA1G
SHANK3 inhibits KMT2A
SHANK3 inhibits SETD1A
SHANK3 inhibits KMT2B
SHANK3 expressed_in GAIN
SHANK3 inhibits KCNH7
SHANK3 expressed_in SHANK1
SHANK3 associated_with Als