protein 660 words KG: SHANK2PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

SHANK2 Gene — SH3 and Multiple Ankyrin Repeat Domains 2

🔬 Protein Info
Gene SymbolSHANK2
Full NameSHANK2 Gene — SH3 and Multiple Ankyrin Repeat Domains 2
Chromosome11q13.2
Protein TypeScaffold Protein
FunctionThe SHANK2 gene encodes a scaffold protein involved in various neurological processes:
Primary Expressiondendritic spines where it organizes the postsynaptic machinery, regulating synaptic transmission and plasticity
Amino Acids630 aa
PathwaysApoptosis
UniProt IDQ9UQB8
NCBI Gene ID22941
Ensembl IDENSG00000141013
GeneCardsSHANK2
Human Protein AtlasSHANK2
Associated Diseasesneurodegeneration
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses