| Gene Symbol | SIGMA1RECEPTOR |
| Aliases | SIGMA1RECEPTOR |
| Subcellular Localization | ** | Endoplasmic reticulum, mitochondrial membrane | |
| Transmembrane architecture | Type III membrane protein with two transmembrane helices |
| Ligand binding | Binds a variety of ligands including (+)-pentazocine, SA4503, and donepezil |
| Oligomerization | Forms homodimers and higher-order oligomers |
| Ca<sup>2+</sup> binding | C-terminal domain binds Ca<sup>2+</sup> with moderate affinity |
| PDZ-binding motif | C-terminal PDZ-binding sequence for protein interactions |
| ER chaperone function | Helps fold and regulate ER-resident proteins[@hayashi2007] |
| Protein quality control | Targets misfolded proteins for degradation |
| Calcium homeostasis | Modulates ER Ca<sup>2+</sup> store release |
| Mitochondrial dynamics | Regulates mitochondrial fission and fusion[@hayashi2007] |
| Bioenergetics | Maintains mitochondrial membrane potential |
| Mitochondrial calcium | Modulates mitochondrial Ca<sup>2+</sup> uptake |
| ER stress response | Activates UPR signaling pathways[@matsumoto2016] |
| Anti-apoptotic signaling | Blocks caspase activation |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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