protein 2,130 words KG: SIN3APROTEIN 2026-03-30
kind:proteinsection:proteinstopic:sin3atopic:transcriptional-repressiontopic:hdacstate:published
Contents

SIN3A Protein — SWI-Independent 3A Transcriptional Regulator

🔬 Protein Info
Gene SymbolSIN3APROTEIN
AliasesSIN3APROTEIN
Subcellular Localization</strong></td><td>Nucleus (chromatin-associated)</td></tr>
PhosphorylationKinases including CK2 and ATM phosphorylate SIN3A, modulating its interaction with partners and nuclear localization
AcetylationSIN3A itself can be acetylated, which may affect protein-protein interactions
SumoylationSumo modification influences transcriptional repression activity
UbiquitinationPolyubiquitination can target SIN3A for proteasomal degradation under certain conditions
SIN3AScaffold protein providing multiple interaction surfaces
HDAC1 and HDAC2Catalytic subunits with histone deacetylase activity
SAP18 and SAP30Adaptor proteins that bridge SIN3A to HDACs
RBBP4/RBBP7 (RbAp46/48)Histone chaperones that orient nucleosomes for deacetylation
CDK11p46A kinase that phosphorylates SIN3A complex components
REST corepressor (CoREST)For neuron-specific gene repression
Methyltransferases (SUV39H1, G9a)For histone methylation
LSD1 (KDM1A)For histone H3K4 demethylation
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.42
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.36
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in