protein 768 words KG: SOD1PROTEINEXPANDED 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

SOD1 Protein

🔬 Protein Info
Gene SymbolSOD1
Full NameSuperoxide Dismutase 1
AliasesSOD1PROTEINEXPANDED
Chromosome21q22.11
Protein TypeEnzyme
Functionis a copper/zinc-dependent enzyme that catalyzes the dismutation of superoxide radical (O₂⁻) into molecular oxygen (O₂) and hydrogen peroxide (H₂O₂).
Primary ExpressionMotor cortex, Spinal cord, Widespread throughout CNS
Molecular Weight~32 kDa (dimer)
Amino Acids154 aa
PathwaysAmyloid, Apoptosis, Autophagy, Epigenetic, Er Stress
Ensembl IDENSG00000142168
GeneCardsSOD1
Human Protein AtlasSOD1
FeatureDetails
Subunit Size16 kDa (154 aa)
Associated DiseasesAD, ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, ARM, Aging
Known Drugs/CompoundsTOFERSEN, RAPAMYCIN, Lactiplantibacillus plantarum FRT4, Antisense Oligonucleotides, Tofersen, Amyloid-Beta Oligomers
InteractionsCALCINEURIN, ATG12, ATG10, GAIN, TNF, PLEKHG5
KG Connections2095 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Cryptic Exon Silencing Restoration
Score: 0.46
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (8)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (4)

s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in