| Gene Symbol | SPTLC1 |
| Full Name | SPTLC1 - Serine Palmitoyltransferase |
| Aliases | Page for SPTLC1, Serine Palmitoyltransferase 1 |
| Chromosome | 9q22.31 |
| Protein Type | Gene |
| Target Class | Protein |
| Function | The canonical reaction catalyzed by SPT involves the condensation of L-serine with palmitoyl-CoA (C16:0) to produce 3-ketosphinganine, which is subsequently reduced to sphinganine (dihydrosphingosine) |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: APOE-Mediated Synaptic Lipid Raft Stabilization |
| Primary Expression | Ubiquitous, highest in brain, liver, kidney |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase I |
| Molecular Weight | ~53 kDa |
| Amino Acids | 473 aa |
| Pathways | Cholesterol, Sphingolipid biosynthesis, Sphingolipid metabolism |
| UniProt ID | O15269 |
| NCBI Gene ID | 10578 |
| GeneCards | SPTLC1 |
| Human Protein Atlas | SPTLC1 |
| Associated Diseases | ALS, Amyotrophic Lateral Sclerosis, Early-Onset Motor Neuron Disease, Juvenile Amyotrophic Lateral Sclerosis |
| Interactions | ORMDL proteins, SPTLC2, ABCA1, RAB7, ALS, RNA |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | APOE-Mediated Synaptic Lipid Raft Stabilization |
| KG Connections | 226 knowledge graph edges |
| Databases | GeneCardsHPASTRING |