| Gene Symbol | TWIK |
| Full Name | 2 Protein — Potassium Two-Pore Domain Channel 6 |
| Aliases | TWIK2PROTEIN |
| Function | TWIK-2 (Two-Pore Domain Potassium Channel 2), encoded by the KCNK6 gene, is a member of the two-pore domain potassium (K2P) channel family. |
| Subcellular Localization | </strong></td><td>Plasma membrane</td></tr> |
| GeneCards | TWIK |
| Human Protein Atlas | TWIK |
| pH | Sensitive to intracellular pH changes |
| Voltage | Weakly voltage-dependent background current |
| Lipids | Modulated by phospholipids and arachidonic acid |
| Hypoxia | Regulated by oxygen-sensing mechanisms |
| Microglial priming | K2P channels regulate microglial membrane potential; their modulation can influence pro-inflammatory cytokine release (TNF-α, IL-1β, IL-6) |
| Oxidative stress | Channel dysfunction may exacerbate reactive oxygen species (ROS) production |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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