Enteric Nervous System Prion-Like Propagation Blockade

graph TD
    A["Dysbiotic Gut<br/>Microbiome"] --> B["Bacterial LPS<br/>Production"]
    B --> C["TLR4 Activation<br/>on Enteric Neurons"]
    C --> D["MyD88 and TRIF<br/>Recruitment"]
    D --> E["NF-kappaB and IRF3<br/>Signaling"]
    E --> F["Pro-inflammatory<br/>Cytokine Release<br/>(IL-1beta, TNF-alpha)"]
    F --> G["Neuroinflammation<br/>in ENS"]
    G --> H["Enhanced alpha-Synuclein<br/>Aggregation"]
    H --> I["Prion-like<br/>alpha-Synuclein<br/>Formation"]
    I --> J["Cell-to-Cell<br/>Transmission<br/>in ENS"]
    J --> K["Vagus Nerve<br/>Propagation"]
    K --> L["CNS alpha-Synuclein<br/>Pathology"]
    L --> M["Neurodegeneration"]
    N["TLR4 Antagonists"] -->|"Therapeutic<br/>Blockade"| C
    O["Microbiome<br/>Restoration"] -->|"Therapeutic<br/>Intervention"| A
    P["Vagotomy"] -->|"Surgical<br/>Intervention"| K

    classDef normal fill:#4fc3f7,color:#0d0d1a
    classDef therapeutic fill:#81c784,color:#0d0d1a
    classDef pathology fill:#ef5350,color:#0d0d1a
    classDef outcome fill:#ffd54f,color:#0d0d1a
    classDef molecular fill:#ce93d8,color:#0d0d1a

    class A,B pathology
    class C,D,E,F,G,H,I,J,K molecular
    class L,M outcome
    class N,O,P therapeutic