| Gene Symbol | SEC61A1 |
| Full Name | Sec61 Translocon Alpha 1 |
| Aliases | Page for SEC61A1, Page for SEC61A1 Protein |
| Chromosome | 3q21.3 |
| Function | Co-translational Translocation: As the ribosome synthesizes a nascent polypeptide with an ER signal sequence, the Sec61 channel allows the growing chain to pass directly into the ER lumen [2] |
| Primary Expression | Cerebral cortex, Hippocampus, Basal ganglia, Spinal cord |
| Molecular Weight | 52 kDa |
| UniProt ID | P61019 |
| NCBI Gene ID | 29927 |
| Ensembl ID | ENSG00000058262 |
| OMIM | 609163 |
| GeneCards | SEC61A1 |
| Human Protein Atlas | SEC61A1 |
| High Protein Synthesis | Neurons have extremely high rates of protein synthesis, particularly at synapses |
| Secretory Pathway Traffic | Synaptic proteins, receptors, and neurotransmitters require proper ER processing |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis |
| Databases | GeneCardsHPASTRING |
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