| Gene Symbol | SHANK1 |
| Full Name | SH3 and Multiple Ankyrin Repeat Domains 3 |
| Aliases | Postsynaptic Scaffold |
| Protein Type | Protein |
| Function | Scaffold Assembly: Shank1 connects membrane proteins to the actin cytoskeleton |
| Subcellular Localization | dendrites, where local translation occurs in response to synaptic activity. The protein is enriched in the postsynaptic |
| Molecular Weight | 230 kDa |
| Amino Acids | 2160 aa |
| UniProt ID | Q9Y2X2 |
| GeneCards | SHANK1 |
| Human Protein Atlas | SHANK1 |
| Organizes PSD | Forms the core of the postsynaptic density |
| Links receptors to cytoskeleton | Connects AMPA/NMDA receptors to actin |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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