Contents

SLC39A8

🧬 Gene Info

Gene Symbol	SLC39A8
Full Name	Solute Carrier Family 39 Member 8
Chromosome	4q24
Protein Type	Transporter
Function	SLC39A8 encodes the zinc and iron transporter protein ZIP8 (also called Zrt- and Irt-like protein 8).
Primary Expression	dopaminergic neurons of the substantia nigra, making it particularly relevant to Parkinson's disease pathogenesis
Amino Acids	462 aa
UniProt ID	[Q9C0K1](https://www.uniprot.org/uniprot/Q9C0K1)
Ensembl ID	ENSG00000138821
OMIM	608732
GeneCards	SLC39A8
Human Protein Atlas	SLC39A8
Zinc transport	ZIP8 mediates cellular zinc uptake, essential for enzyme function, protein structure, and signaling pathways[@liu2023]
Iron homeostasis	The transporter also imports iron, crucial for mitochondrial function and neurotransmitter synthesis[@wang2022]
Blood-brain barrier permeation	SLC39A8 expression on endothelial cells of the BBB allows metal entry into the brain[@gomes2021]
Associated Diseases	ALS, inflammatory bowel disease, kidney disease, neurodegeneration
Interactions	KCNK2
KG Connections	14 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph