concept

AKT1S1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT1S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

187Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

AKT1S1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, expressed in. Associated with ALS, Cancer, Fibrosis. Connected to 78 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameAKT1S1
Key Genes/ProteinsSLC39A8, ROS, HMGB1, ATG16L1, EGF, NBR1
Related DiseasesFibrosis, ALS, Cancer, Als
Related PathwaysOxidative Phosphorylation, Autophagy, Mtor

Wiki Pages (1)

Knowledge base pages for this entity

SLC39A8

gene · 528 words

Pathway Diagram

graph TD
    AKT1S1["AKT1S1"]
    AKT1S1 -->|"regulates"| Fibrosis["Fibrosis"]
    AKT1S1 -->|"interacts"| ALS["ALS"]
    AKT1S1 -->|"interacts"| Cancer["Cancer"]
    AKT1S1 -->|"regulates"| ROS["ROS"]
    AKT1S1 -->|"interacts"| HMGB1["HMGB1"]
    AKT1S1 -->|"regulates"| ATG16L1["ATG16L1"]
    AKT1S1 -->|"interacts"| EGF["EGF"]
    AKT1S1 -->|"interacts"| NBR1["NBR1"]
    AKT1S1 -->|"interacts"| RPS6KB1["RPS6KB1"]
    AKT1S1 -->|"interacts"| MLST8["MLST8"]
    SLC39A8["SLC39A8"] -->|"regulates"| AKT1S1
    STAT3["STAT3"] -->|"interacts"| AKT1S1
    EGFR["EGFR"] -->|"interacts"| AKT1S1
    DEPTOR["DEPTOR"] -->|"interacts"| AKT1S1
    MLKL["MLKL"] -->|"interacts"| AKT1S1
    RAS["RAS"] -->|"interacts"| AKT1S1
    EIF2A["EIF2A"] -->|"interacts"| AKT1S1
    RB1CC1["RB1CC1"] -->|"interacts"| AKT1S1
    GABARAP["GABARAP"] -->|"interacts"| AKT1S1
    AMBRA1["AMBRA1"] -->|"regulates"| AKT1S1

Outgoing (99)

TargetRelationTypeStr
Fibrosisregulatesdisease0.65
ALSinteracts_withdisease0.65
Cancerinteracts_withdisease0.65
Alsinteracts_withdisease0.65
ROSregulatesgene0.60

Incoming (88)

SourceRelationTypeStr
SLC39A8regulatesgene0.70
STAT3interacts_withgene0.60
EGFRinteracts_withgene0.60
DEPTORinteracts_withgene0.60
MLKLinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found