Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AKT1S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AKT1S1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, expressed in. Associated with ALS, Cancer, Fibrosis. Connected to 78 entities in the SciDEX knowledge graph.
| Name | AKT1S1 |
| Key Genes/Proteins | SLC39A8, ROS, HMGB1, ATG16L1, EGF, NBR1 |
| Related Diseases | Fibrosis, ALS, Cancer, Als |
| Related Pathways | Oxidative Phosphorylation, Autophagy, Mtor |
Knowledge base pages for this entity
graph TD
AKT1S1["AKT1S1"]
AKT1S1 -->|"regulates"| Fibrosis["Fibrosis"]
AKT1S1 -->|"interacts"| ALS["ALS"]
AKT1S1 -->|"interacts"| Cancer["Cancer"]
AKT1S1 -->|"regulates"| ROS["ROS"]
AKT1S1 -->|"interacts"| HMGB1["HMGB1"]
AKT1S1 -->|"regulates"| ATG16L1["ATG16L1"]
AKT1S1 -->|"interacts"| EGF["EGF"]
AKT1S1 -->|"interacts"| NBR1["NBR1"]
AKT1S1 -->|"interacts"| RPS6KB1["RPS6KB1"]
AKT1S1 -->|"interacts"| MLST8["MLST8"]
SLC39A8["SLC39A8"] -->|"regulates"| AKT1S1
STAT3["STAT3"] -->|"interacts"| AKT1S1
EGFR["EGFR"] -->|"interacts"| AKT1S1
DEPTOR["DEPTOR"] -->|"interacts"| AKT1S1
MLKL["MLKL"] -->|"interacts"| AKT1S1
RAS["RAS"] -->|"interacts"| AKT1S1
EIF2A["EIF2A"] -->|"interacts"| AKT1S1
RB1CC1["RB1CC1"] -->|"interacts"| AKT1S1
GABARAP["GABARAP"] -->|"interacts"| AKT1S1
AMBRA1["AMBRA1"] -->|"regulates"| AKT1S1| Target | Relation | Type | Str |
|---|---|---|---|
| Fibrosis | regulates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| ROS | regulates | gene | 0.60 |
| HMGB1 | interacts_with | gene | 0.60 |
| ATG16L1 | regulates | gene | 0.60 |
| EGF | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| RPS6KB1 | interacts_with | gene | 0.60 |
| MLST8 | interacts_with | gene | 0.60 |
| Oxidative Phosphorylation | interacts_with | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Mtor | interacts_with | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| Wnt | regulates | pathway | 0.60 |
| GABARAP | interacts_with | gene | 0.60 |
| RIPK1 | interacts_with | gene | 0.60 |
| MAP1LC3A | interacts_with | gene | 0.60 |
| GRB2 | interacts_with | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MLKL | interacts_with | gene | 0.60 |
| ATP | regulates | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| AMPK | regulates | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| CFTR | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| IFNG | interacts_with | gene | 0.60 |
| MTORC1 | interacts_with | gene | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| PIK3C3 | interacts_with | gene | 0.60 |
| PPARG | interacts_with | gene | 0.60 |
| TFEB | interacts_with | gene | 0.60 |
| GABA | interacts_with | gene | 0.60 |
| ATG | regulates | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| JNK | regulates | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| RHEB | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| DEPTOR | interacts_with | gene | 0.60 |
| CGAS | regulates | gene | 0.60 |
| STAT3 | interacts_with | gene | 0.60 |
| IFN | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC39A8 | regulates | gene | 0.70 |
| STAT3 | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| DEPTOR | interacts_with | gene | 0.60 |
| MLKL | interacts_with | gene | 0.60 |
| RAS | interacts_with | gene | 0.60 |
| EIF2A | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| GABARAP | interacts_with | gene | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| ATF6 | regulates | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| GRB2 | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| RPTOR | interacts_with | gene | 0.60 |
| CALCOCO2 | regulates | gene | 0.60 |
| PIK3C3 | interacts_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| CFTR | regulates | gene | 0.60 |
| CGAS | regulates | gene | 0.60 |
| PPARG | interacts_with | gene | 0.60 |
| OPTINEURIN | interacts_with | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| P38 | interacts_with | gene | 0.60 |
| MTORC1 | interacts_with | gene | 0.60 |
| ATG | regulates | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| JNK | regulates | gene | 0.60 |
| RIPK1 | interacts_with | gene | 0.60 |
| AMPK | regulates | gene | 0.60 |
| LYSOSOME | interacts_with | gene | 0.60 |
| APC | regulates | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| MAP1LC3A | interacts_with | gene | 0.60 |
| ATP | regulates | gene | 0.60 |
| HSP70 | interacts_with | gene | 0.60 |
| TFE3 | interacts_with | gene | 0.60 |
| MAPK14 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
| AKT1 | regulates | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| IFN | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||