| Gene Symbol | PARK9 |
| N-terminal regulatory region | Cytoplasmic |
| Transmembrane domains | Membrane-spanning |
| ATP-binding domain | Cytoplasmic |
| C-terminal tail | Cytoplasmic |
| Pathogenic Mechanism | Cellular Consequence |
| Lysosomal dysfunction | Impaired acidification, reduced cathepsin activity, lipofuscin accumulation |
| Autophagy blockade | Accumulation of autophagosomes, failed mitophagy |
| Metal dysregulation | Manganese and zinc accumulation, iron-induced oxidative stress |
| ER stress | Unfolded protein response activation |
| Alpha-synuclein accumulation | Protein aggregation and Lewy body formation |
| Dopaminergic neuron loss | Motor and cognitive deficits |
| Vector | Promoter |
| AAV9 | Synapsin |
| AAVrh.10 | CAG |
| AAV2 | Synapsin |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |