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therapeutic 744 words KG: ent-gene-4d6f2924
Contents

bace1-inhibitors-alzheimers

🔬 Protein Info
Gene Symbolent-gene-4d6f2924
DrugCompany
Verubecestat (MK-8931)Merck
Lanabecestat (AZD3293)AstraZeneca/Eli Lilly
Atabecestat (JNJ-54861911)Janssen
Elenbecestat (E2609)Eisai
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate
Score: 0.61Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedCell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed

Related Experiments (5)

ASC antibody treatment in SH-SY5Y-APP695 cells
exploratory · proposed · Score: 0.90Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
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