therapeutic 1,963 words KG: ent-gene-ac0dd25b
Contents

cdnf-therapy-parkinsons

🔬 Protein Info
Gene Symbolent-gene-ac0dd25b
Trial IDNCT05823401
AgentAAV-CDNF (AAV2-CDNF)
PhasePhase 1/2
StatusActive
IndicationParkinson's Disease
DeliveryIntraparenchymal (brain surgery)
SponsorHerantis Pharma
FactorTarget
CDNFDopaminergic neurons
GDNFDopaminergic neurons
BDNFBroad neuronal
NRTN (Neurturin)Dopaminergic neurons
FeatureCDNF (Original)
InvasivenessHigh ( stereotactic surgery)
Patient AcceptanceLow (requires brain implant)
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Vagal Afferent Microbial Signal Modulation
Score: 0.52
Vocal Cord Neuroplasticity Stimulation
Score: 0.50
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.69

Related Analyses (20)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40
Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-ac0dd25b data_in benchmark_ot_ad_answer_key:CDNF
benchmark_ot_ad_answer_key:CDNF data_in ent-gene-ac0dd25b