| Gene Symbol | ent-gene-45b60f3e |
| Feature | Entacapone |
| Generation | First |
| Dosing | With each levodopa dose |
| COMT inhibition | ~65% |
| CNS penetration | No |
| ON time increase | 1-2 hours |
| Hepatotoxicity risk | No |
| Liver monitoring | Not required |
| Approval year | 1998/1999 |
| Drug | Selectivity |
| Entacapone | Selective |
| Tolcapone | Non-selective |
| Opicapone | Selective |
| Parameter | With COMT-I |
| OFF time reduction | 1-2 hours |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |