therapeutic 1,500 words KG: ent-gene-16cf4081 2026-03-23
kind:therapeuticsection:therapeuticsstate:published
Contents

CSF1R Modulation Therapy

🔬 Protein Info
Gene Symbolent-gene-16cf4081
StudyModel
Daggett et al., 2020APP/PS1
Spangenberg et al., 2019APP/PS1
Elmore et al., 20215xFAD
TrialPhase
NCT04731254Phase 1
NCT04893564Phase 2
NCT05139615Phase 1/2
FeatureCSF1R Inhibition
MechanismDeplete microglia
Target specificityBroad
Clinical stagePhase 1/2
Risk profileModerate
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (24)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40

See Also (15)

Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 3 hypotheses
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 3 hypotheses
Therapeutic Targets in Neurodegeneration
mechanism · Pages share 3 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 3 hypotheses
Sex Differences in Neurodegeneration
mechanism · Pages share 3 hypotheses