therapeutic 2,706 words KG: ent-gene-16cf4081 2026-03-22
kind:therapeuticsection:therapeuticsstate:published
Contents

CSF-1R Inhibitors

🔬 Protein Info
Gene SymbolCSF
Full Name1R Inhibitors
Chromosome5q33.2.
GeneCardsCSF
Human Protein AtlasCSF
Adverse EventFrequency
Elevated ALT/AST15-25%
Fatigue20-30%
Nausea20-30%
Hair depigmentation60-70%
Rash15-25%
Thrombocytopenia20-35%
Headache15-20%
GI disturbances10-15%
CompoundCompany
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61

Related Analyses (6)

Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (30)

FLS Stimulation and Transcriptomic Analysis
exploratory · proposed · Score: 0.95
iPSC-derived endothelial cell iron uptake with RLS CSF expos
exploratory · proposed · Score: 0.90
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
CSF iron content analysis in RLS patients versus controls
clinical · proposed · Score: 0.85
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

Key Papers (1)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024