therapeutic 947 words KG: ent-gene-9f063e98
kind:therapeuticsection:therapeuticsstate:publishedtopic:parkinsons
Contents

G007-LK: LRRK2 Kinase Inhibitor

🔬 Protein Info
Gene SymbolG007
Full NameLK: LRRK2 Kinase Inhibitor
GeneCardsG007
Human Protein AtlasG007
ParameterValue
Oral bioavailability>60% (rat), >50% (dog)
Brain-to-plasma ratio1.2-1.5
Half-life (rodent)4-6 hours
Once-daily dosingSuitable
CYP inhibitionLow (favorable drug-drug interaction profile)
Development StagePreclinical / IND-enabling
CompanyVanqua Bio (collaboration with Genentech/Roche)
IndicationParkinson's disease (LRRK2 mutation carriers)
RouteOral (small molecule)
DosingOnce-daily
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph